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pentobarbital will decrease the extent or effect of saxagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.Contraindicated (1)pentobarbital will lower the extent or effect of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the development and elim